An intrasubject replication strategy for evaluating occlusal splint therapy.

Okeson and others have proposed that statistical comparisons between groups of treated and untreated patients be used to evaluate the effectiveness of occlusal splint therapy. This article argues that valid between-groups comparisons cannot be made by most clinicians and that such comparisons do not satisfactorily guide the treatment of individual patients. An intrasubject replication design strategy is then offered as a model for clinicians to use in evaluating splint-therapy effects in individual